Advances in Clinical Medical Research https://acmrjournal.com/index.php/acmr <p><strong>Advances in Clinical Medical Research (ACMR)</strong> is an open-access, freely accessible, online and print quarterly peer-reviewed international journal publishes a wide spectrum of advanced research on all medical specialties including ethical and social issues. ACMR is a gateway to enlighten the latest research/issues happening all around the world of medical and health sciences.</p> Advances in Clinical Medical Research 2 Oakfield Place, St. Paul's Road, Clifton, Bristol, England, United Kingdom- BS8 2BJ Phone: +44-7833277351 en-US Advances in Clinical Medical Research 2635-0815 Obesity in Women of Reproductive Age https://acmrjournal.com/index.php/acmr/article/view/43 <p>This article provides information about the relationship between obesity and disorders of the reproductive system. Lifestyle factors are changeable habits and lifestyles that can greatly affect overall health and well-being, including fertility. Overweight contributes to menstrual cycle disorders, infertility, miscarriage, unfavorable pregnancy outcome, deterioration of fetal well-being and diabetes mellitus.</p> Dilafruzhon Ravshanovna Maksudova Khurshidakhon Kudratullayevna Nasyrova Copyright (c) 2022 Author https://creativecommons.org/licenses/by/4.0/ 2022-07-08 2022-07-08 3 3 1 4 Habitual Miscarriage of Pregnancy with Endocrine Disorders https://acmrjournal.com/index.php/acmr/article/view/44 <p>This article presents information about the relationship of habitual miscarriage with endocrine pathology. Endocrine factors in 75% of cases are the cause of complicated pregnancy up to 20 weeks. Untimely and inadequate therapy of complications of early pregnancy leads to termination of pregnancy not only in the first trimester, but also in later gestation.</p> Mukhammedaminova Diyora Timurovna Nasyrova Khurshidakhon Kudratullayevna Copyright (c) 2022 Author https://creativecommons.org/licenses/by/4.0/ 2022-07-08 2022-07-08 3 3 5 8 Modern Possibilities of Immunoprophylaxis of Prolonged Course of Community-Acquired Pneumonia in Children https://acmrjournal.com/index.php/acmr/article/view/45 <p>The aim of the study was to develop methods for the prevention of prolonged community-acquired pneumonia in children. 180 children aged 6 months to 15 years with community-acquired pneumonia of a prolonged course, who are being treated in the department of pulmonology, were examined. Analysis of anamnestic data showed that all children, regardless of the development of the disease, had repeatedly suffered acute respiratory infections, pneumonia, intestinal infections, purulent-septic diseases, characterized by a long, recurrent course and difficult to respond to antimicrobial therapy.</p> Furkat Mukhitdinovich Shamsiev Nilufar Irgashevna Karimova Safura Nosirjonovna Zaynabitdinova Copyright (c) 2022 Author https://creativecommons.org/licenses/by/4.0/ 2022-07-08 2022-07-08 3 3 9 11 Modern Aspects of Risk Factors for the Formation of Bronchial Asthma in Children https://acmrjournal.com/index.php/acmr/article/view/46 <p>The purpose of our study was to study the nature of clinical manifestations and risk factors for the development of bronchial asthma (BA) in children. We examined 120 children aged 5 to 15 years with asthma who were on inpatient treatment in the department of pulmonology and allergology. With moderate and severe asthma, there was a longer manifestation of shortness of breath, oral wheezing, wet cough and wet wheezing in the lungs, emphysematous lung enlargement on both sides with horizontal standing of the ribs. In the presence of severe bronchospasm, the symptoms of intoxication and respiratory failure were more pronounced, which is manifested by long-term clinical signs of the disease. Among the main risk factors for the development of AD, hereditary burden, peculiarities of maternal nutrition during pregnancy and lactation, early transfer of the child to mixed and artificial feeding, unfavorable course of the peri–, intranatal periods and comorbid background can be distinguished.</p> Furkat Mukhitdinovich Shamsiev Nilufar Irgashevna Karimova Zamirahon Olimjonovna Urumboeva Copyright (c) 2022 Author https://creativecommons.org/licenses/by/4.0/ 2022-07-08 2022-07-08 3 3 12 14 Immunological and Biochemical Features in Bronchial Asthma in Children https://acmrjournal.com/index.php/acmr/article/view/47 <p>The aim of our study was to study the indicators of cytokine status and to determine the features of the hemostasis system and the acid-base state in children with bronchial asthma. We examined 25 children with bronchial asthma aged 7 to 14 years. The study program included: the determination of the level of cytokines: IL-1β and IL-8, the determination of the activity of the acid-base state of the blood. The results of the study showed that the development of bronchial asthma is facilitated by the unfavorable course of the peri- and intranatal periods, aggravated premorbid background, concomitant and past diseases, and significantly high levels of pro-inflammatory cytokines IL-1β and IL-8 were revealed. From the side of biochemical indicators, a very low level of prothrombin time, mild metabolic alkalosis, low partial pressure of oxygen in the blood, and a decrease in the concentration of potassium and calcium ions were detected.</p> Furkat Mukhitdinovich Shamsiev Nilufar Irgashevna Karimova Copyright (c) 2022 Author https://creativecommons.org/licenses/by/4.0/ 2022-07-08 2022-07-08 3 3 15 17