Advances in Clinical Medical Research <p><strong>Advances in Clinical Medical Research (ACMR)</strong> is an open-access, freely accessible, online and print quarterly peer-reviewed international journal publishes a wide spectrum of advanced research on all medical specialties including ethical and social issues. ACMR is a gateway to enlighten the latest research/issues happening all around the world of medical and health sciences.</p> en-US (Dr Megha Garg) (Dr Megha Garg) Wed, 13 Apr 2022 04:33:52 +0000 OJS 60 The Use of Leukotriene Inhibitors as Basic Therapy in Children with Bronchial Asthma <p>In the pharmacotherapy of bronchial asthma, a ”step-by-step” approach is recommended, which includes an increase or decrease in the volume of therapy, depending on the severity of clinical symptoms. In complex therapy, it is possible to use non-drug methods of treatment, although the effectiveness of some of them is debatable and needs further study. To achieve this goal, children over the age of 3 years (the group of patients consisted of 26 children) with different forms and degrees of severity of bronchial asthma were included in the study. Patients of&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; the main group took L-Montus (montelukast), children of the ketotifen comparison group. Leukotriene receptor antagonists (montelukast, zafirlukast) are the first mediator-specific therapy of AD and represent a new therapeutic class of drugs in the treatment of the disease. The effectiveness of leukotriene receptor antagonists has been proven in randomized clinical trials among adults and children with bronchial asthma. Leukotriene receptor blockers, in particular L-Montus relieves the symptoms of AD and is a drug for the basic therapy of this disease, leads to a significant improvement in control, reduces the frequency of exacerbations of AD caused by viral infection in children aged 3-5 years. It has an anti-inflammatory effect, complementary to the action of glucocorticosteroids.</p> Zebo Norboboevna Sherova, Kamola Yuldasheva Normatova , Kamala Shakhamdamovna Shaabidova Copyright (c) 2022 Author Wed, 13 Apr 2022 00:00:00 +0000 Knowledge and Attitude towards Psychiatry among Nursing Staffs in Tertiary Health Care Hospital <p>Type 2 diabetes mellitus (DM) is one of the most common noncommunicable diseases on the globe. If at present the number of patients with diabetes in the world is 347 million people, then by 2025, according to scientists, this figure will reach at least 592 million, of which 90% will be in diabetes. Global trends in the incidence of type 2 diabetes are also observed in Uzbekistan. The total number of patients with diabetes in Uzbekistan amounted to 230610 (706.24 per 100 thousand people), of which type 1 diabetes – 18349 (56.2 per 100 thousand people), type 2 diabetes – 212261 (650,0 per 100 thousand people). As a percentage, patients with type 1 diabetes of the total number of patients with diabetes is 8.0%, patients with type 2 diabetes are 92.0%. Maintaining a constantly normal or near normal concentration of glucose in the blood slows down the onset and progression of late complications of type 2 diabetes. In the absence of achieving the target glycemic values against the background of the use of a rational combination of oral hypoglycemic drugs, it is shown that baseline action is added to insulin treatment to suppress liver gluconeogenesis and normalize fasting glucose. The combination of sulfonylurea derivatives (PSM) and basal insulin has been well studied and has proven. In addition, the combined use of metformin and insulin was widely used in the treatment of patients with type 2 diabetes mellitus (T2DM), however, at present there is no evidence base in favor of their joint appointment.</p> Zilola Aramovna Djuraeva, Gulnora Siddiqovna Togaeva, Aziza Davranovna Davranova Copyright (c) 2022 Author Wed, 13 Apr 2022 00:00:00 +0000 Features of Thyroid Function in Patients with Metabolic Syndrome <p>According to the results of the largest epidemiological studies, the prevalence of hypothyroidism in women is 4-21% and 3-16% in men and is characterized by a significant increase in its frequency among older people. In this connection, the study of the relationship of these diseases is relevant in order to improve diagnosis and treatment. We came to the conclusion that in patients suffering from MS average TSH level is higher than in people of the same age without metabolic syndrome, and with an increase in the number of MS components, a decrease in the functional activity of the thyroid gland occurs.</p> Zilola Aramovna Djuraeva, Aziza Davranovna Davranova Copyright (c) 2022 Author Wed, 13 Apr 2022 00:00:00 +0000